Author Wirths, Oliver

• 2024 | Journal Article
  ​ ​Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimer’s disease​
  Morgado, B.; Klafki, H.-W.; Bauer, C.; Waniek, K.; Esselmann, H.; Wirths, O. & Hansen, N. et al.​ (2024) 
  European Archives of Psychiatry and Clinical Neuroscience,.​ DOI: https://doi.org/10.1007/s00406-023-01751-2 
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• 2023 | Journal Article | 
  ​ ​A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner​
  Remling, L.; Gregus, A.; Wirths, O.; Meyer, T. & Staab, J. F. ​ (2023) 
  Cell Communication and Signaling, 21(1) art. 170​.​ DOI: https://doi.org/10.1186/s12964-023-01124-1 
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• 2023 | Journal Article | 
  ​ ​A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model​
  Stazi, M.; Zampar, S.; Klafki, H.-W.; Meyer, T. & Wirths, O.​ (2023) 
  International Journal of Molecular Sciences, 24(3).​ DOI: https://doi.org/10.3390/ijms24032155 
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• 2023 | Journal Article
  ​ ​Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS​
  Liepold, T.; Klafki, H.-W.; Kumar, S.; Walter, J.; Wirths, O.; Wiltfang, J. & Jahn, O.​ (2023) 
  Journal of the American Society for Mass Spectrometry, art. jasms.2c00270​.​ DOI: https://doi.org/10.1021/jasms.2c00270 
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• 2023 | Journal Article | 
  ​ ​Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice​
  Bader, A. S.; Gnädig, M.-U.; Fricke, M.; Büschgens, L.; Berger, L. J.; Weggen, S. & Klafki, H.-W. et al.​ (2023) 
  Life, 13(4) pp. 1053​.​ DOI: https://doi.org/10.3390/life13041053 
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• 2023 | Journal Article
  ​ ​Blood plasma biomarkers for Alzheimer’s disease: Aβ1–42/1–40 vs. AβX–42/X–40​
  Klafki, H.-W.; Wirths, O.; Jahn, O.; Morgado, B.; Esselmann, H. & Wiltfang, J.​ (2023) 
  Clinical Chemistry and Laboratory Medicine,.​ DOI: https://doi.org/10.1515/cclm-2023-0990 
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• 2023 | Preprint
  ​ ​Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer’s disease​
  Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Yu, X.& Boehler, C. et al.​ (2023). DOI: https://doi.org/10.1101/2023.12.11.570514 
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• 2022 | Journal Article | 
  ​ ​Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?​
  Klafki, H.-W.; Morgado, B.; Wirths, O.; Jahn, O.; Bauer, C.; Esselmann, H. & Schuchhardt, J. et al.​ (2022) 
  Fluids and Barriers of the CNS, 19(1) art. 96​.​ DOI: https://doi.org/10.1186/s12987-022-00390-4 
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• 2022 | Journal Article | Research Paper
  ​ ​An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form​
  Menon, P. R.; Staab, J.; Gregus, A.; Wirths, O. & Meyer, T.​ (2022) 
  Cell Communication and Signaling, 20(1) art. 42​.​ DOI: https://doi.org/10.1186/s12964-022-00841-3 
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• 2022 | Journal Article | 
  ​ ​Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice​
  Stazi, M.; Zampar, S.; Nadolny, M.; Büschgens, L.; Meyer, T. & Wirths, O.​ (2022) 
  European Archives of Psychiatry and Clinical Neuroscience,.​ DOI: https://doi.org/10.1007/s00406-022-01431-7 
  ​Details  DOI 

• 2021 | Journal Article | 
  ​ ​Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis​
  Stazi, M.; Lehmann, S.; Sakib, M. S.; Pena-Centeno, T.; Büschgens, L.; Fischer, A. & Weggen, S. et al.​ (2021) 
  Cellular and Molecular Life Sciences, 79(1) art. 55​.​ DOI: https://doi.org/10.1007/s00018-021-04062-8 
  ​Details  DOI 

• 2021 | Journal Article | Research Paper | 
  ​ ​Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease​
  Aichholzer, F.; Klafki, H.-W.; Ogorek, I.; Vogelgsang, J.; Wiltfang, J.; Scherbaum, N. & Weggen, S. et al.​ (2021) 
  Alzheimer's Research & Therapy, 13(1) art. 94​.​ DOI: https://doi.org/10.1186/s13195-021-00828-1 
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• 2016 | Journal Article
  ​ ​Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease​
  Weissmann, R.; Huettenrauch, M.; Kacprowski, T.; Bouter, Y.; Pradier, L.; Bayer, T. A. & Kuss, A. W. et al.​ (2016) 
  Journal of Alzheimer s Disease, 50(2) pp. 397​-409​.​ DOI: https://doi.org/10.3233/JAD-150745 
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• 2016 | Journal Article
  ​ ​N-Truncated A beta(2-X) Starting with Position Two in Sporadic Alzheimer's Disease Cases and Two Alzheimer Mouse Models​
  Savastano, A.; Klafki, H.; Haussman, U.; Oberstein, T. J.; Mueller, P.; Wirths, O. & Wiltfang, J. et al.​ (2016) 
  Journal of Alzheimer s Disease, 49(1) pp. 101​-110​.​ DOI: https://doi.org/10.3233/JAD-150394 
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• 2015 | Journal Article
  ​ ​I716F AβPP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-β and α-Synucleinopathy with Lewy Bodies​
  Sieczkowski, E.; Milenkovic, I.; Venkataramani, V.; Giera, R.; Ströbel, T.; Höftberger, R. & Liberski, P. P. et al.​ (2015) 
  Journal of Alzheimer's Disease, 44(1) pp. 103​-114​.​ DOI: https://doi.org/10.3233/JAD-141524 
  ​Details  DOI 

• 2015 | Journal Article
  ​ ​Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease​
  Richard, B. C. ; Kurdakova, A.; Baches, S.; Bayer, T. A.; Weggen, S. & Wirths, O.​ (2015) 
  Journal of Alzheimer s Disease, 45(4) pp. 1223​-1236​.​ DOI: https://doi.org/10.3233/JAD-143120 
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• 2014 | Journal Article | 
  ​ ​Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing​
  Bouter, Y.; Kacprowski, T.; Weissmann, R.; Dietrich, K.; Borgers, H.; Brauss, A. & Sperling, C. et al.​ (2014) 
  Frontiers in Aging Neuroscience, 6.​ DOI: https://doi.org/10.3389/fnagi.2014.00075 
  ​Details  DOI  WoS 

• 2014 | Review | 
  ​ ​Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease​
  Bayer, T. A.& Wirths, O.​ (2014)
  Acta Neuropathologica, 127​(6) pp. 787​-801​.​
  Springer. DOI: https://doi.org/10.1007/s00401-014-1287-x 
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• 2014 | Journal Article
  ​ ​A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models​
  Reinert, J.; Martens, H.; Huettenrauch, M.; Kolbow, T.; Lannfelt, L.; Ingelsson, M. & Paetau, A. et al.​ (2014) 
  Journal of Alzheimer s Disease, 39(4) pp. 871​-881​.​ DOI: https://doi.org/10.3233/JAD-131373 
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• 2014 | Journal Article | 
  ​ ​Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal A beta accumulation​
  Christensen, D. Z.; Huettenrauch, M. ; Mitkovski, M.; Pradier, L. & Wirths, O.​ (2014) 
  Frontiers in Aging Neuroscience, 6 art. 139​.​ DOI: https://doi.org/10.3389/fnagi.2014.00139 
  ​Details  DOI  PMID  PMC  WoS 

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